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closeAssociation between FADS1 and LDL cholesterol confirmed
Posted by ksuhre on 11 Dec 2008 at 21:14 GMT
Two recent GWA studies with up to 18,000 participants [5],[6] report p-values of association for SNP rs174548 with serum low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol levels that range between 1.89×10−4 and 6.07×10−5 (Table 1). These associations have not been included into the list of potential candidates for replication in those studies, as their p-values taken alone were not sufficiently small in the context of a “classical” GWA study.
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000282#article1.body1.sec2.sec3.p1
The association between FADS1 and LDL cholesterol that was predicted here has been confirmed in a recent study entitled "Genome-wide association analysis of metabolic traits in a birth cohort from a founder population" by Sabatti et al. (Nature Genetcs, 2008, Dec 7).
The abstract reads: We [..] identify nine new associations, several of which highlight genes with metabolic functions: [..] low-density lipoprotein with AR and FADS1-FADS2 ...
Pubmed link:
http://www.ncbi.nlm.nih.gov/pubmed/19060910