Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

Christian Gieger; Ludwig Geistlinger; Elisabeth Altmaier; Martin Hrabé de Angelis; Florian Kronenberg; Thomas Meitinger; Hans-Werner Mewes; H.-Erich Wichmann; Klaus M. Weinberger; Jerzy Adamski; Thomas Illig; Karsten Suhre

doi:10.1371/journal.pgen.1000282

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Research Article

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

Christian Gieger,

Affiliations Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
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Ludwig Geistlinger,

Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
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Elisabeth Altmaier,

Affiliations Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Faculty of Biology, Ludwig-Maximilians-Universität, Planegg-Martinsried, Germany
⨯
Martin Hrabé de Angelis,

Affiliations Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany
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Florian Kronenberg,

Affiliation Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
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Thomas Meitinger,

Affiliations Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
⨯
Hans-Werner Mewes,

Affiliations Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Genome-Oriented Bioinformatics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany
⨯
H.-Erich Wichmann,

Affiliations Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
⨯
Klaus M. Weinberger,

Affiliation Biocrates Life Sciences AG, Innsbruck, Austria
⨯
Jerzy Adamski,

Affiliations Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany
⨯
Thomas Illig,

Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
⨯
Karsten Suhre

* E-mail: karsten.suhre@helmholtz-muenchen.de

Affiliations Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Faculty of Biology, Ludwig-Maximilians-Universität, Planegg-Martinsried, Germany
⨯

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

Christian Gieger,
Ludwig Geistlinger,
Elisabeth Altmaier,
Martin Hrabé de Angelis,
Florian Kronenberg,
Thomas Meitinger,
Hans-Werner Mewes,
H.-Erich Wichmann,
Klaus M. Weinberger,
Jerzy Adamski

Published: November 28, 2008
https://doi.org/10.1371/journal.pgen.1000282

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More GWA studies with metabolic traits

Posted by ksuhre on 20 Jan 2009 at 12:32 GMT

More GWAS with metabolic traits are starting to get published, confirming the high potential of metabolomics in obtaining a functional understanding of human genetic variation and its link to complex diseases.

In the january issue of this journal, Tanaka et al. present a paper that I very much recommend to be read back-to-back with this paper by Gieger et al.

Tanaka et al., Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study, PLoS Genetics, 5(1): e1000338, 2009.

RE: More GWA studies with metabolic traits

PLOS_Genetics replied to ksuhre on 21 Jan 2009 at 09:30 GMT

The following link provides direct access to the study by Tanaka et al: http://www.plosgenetics.o...

RE: More GWA studies with metabolic traits

ksuhre replied to ksuhre on 08 Sep 2011 at 11:25 GMT

Here are some recent GWAS with metabolomics that build on our initial paper:

Human metabolic individuality in biomedical and pharmaceutical research, Nature, 2011, http://www.ncbi.nlm.nih.g....

A genome-wide association study of metabolic traits in human urine, Nature Genetics, 2010, http://www.ncbi.nlm.nih.g....

A genome-wide perspective of genetic variation in human metabolism, Nature Genetics, 2010, http://www.ncbi.nlm.nih.g....

Genetic determinants of circulating sphingolipid concentrations in European populations, PLoS Genetics, 2009, http://www.ncbi.nlm.nih.g....

No competing interests declared.

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Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

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More GWA studies with metabolic traits

Posted by ksuhre on 20 Jan 2009 at 12:32 GMT

RE: More GWA studies with metabolic traits

PLOS_Genetics replied to ksuhre on 21 Jan 2009 at 09:30 GMT

RE: More GWA studies with metabolic traits

ksuhre replied to ksuhre on 08 Sep 2011 at 11:25 GMT