About the Authors

Charleston W. K. Chiang

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

Zofia K. Z. Gajdos

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

Joshua M. Korn

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Finny G. Kuruvilla

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Johannah L. Butler

Affiliation Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

Rachel Hackett

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Candace Guiducci

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Thutrang T. Nguyen

Affiliation Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

Rainford Wilks

Affiliation Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston, Jamaica

Terrence Forrester

Affiliation Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston, Jamaica

Christopher A. Haiman

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Katherine D. Henderson

Affiliation Department of Population Sciences, Division of Cancer Etiology, City of Hope National Medical Center, Duarte, California, United States of America

Loic Le Marchand

Affiliation Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America

Brian E. Henderson

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Mark R. Palmert

Affiliations Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

Colin A. McKenzie

Affiliation Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston, Jamaica

Helen N. Lyon

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

Richard S. Cooper

Affiliation Department of Preventive Medicine and Epidemiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America

Xiaofeng Zhu

Affiliation Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, Ohio, United States of America

Joel N. Hirschhorn

joelh@broadinstitute.org

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CWKC ZKZG JMK FGK MRP JNH. Performed the experiments: CWKC ZKZG JLB RH CG TTN. Analyzed the data: CWKC. Contributed reagents/materials/analysis tools: CWKC JMK RW TF CAH KDH LLM BEH MRP CAM HNL RSC XZ. Wrote the paper: CWKC ZKZG JNH. Interpreted the data: CWKC ZKZG JNH.