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Table of Contents

December 2016

Cover

A Framework for Smart Road Planning
Issue Image

Proposals for new infrastructure in developing countries are typically muted on its environmental impacts, while environmentalists typically say little about its potential benefits for people. This study explores a more conciliatory approach by trying to identify where beneficial infrastructure might be expanded at least environmental cost. Focusing on the Greater Mekong Subregion of Southeast Asia, Balmford et al intersected agricultural, social and environmental maps to identify areas where new roads could help deliver growth in food production at least environmental cost. The image shows a newly established highway serving to overcome mountain barriers in the upper Mekong.

Image Credit: Jianchu Xu and Biaoyun Huai

Open Highlights

Seven Glimpses into the Emotional Brain

Gabriel Gasque

PLOS Biology: published December 19, 2016 | https://doi.org/10.1371/journal.pbio.2001633

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Perspective

Why Having a (Nonfinancial) Interest Is Not a Conflict of Interest

Lisa A. Bero, Quinn Grundy

PLOS Biology: published December 21, 2016 | https://doi.org/10.1371/journal.pbio.2001221

Community Pages

A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine

Ulrich Dirnagl, Ingo Przesdzing, Claudia Kurreck, Sebastian Major

PLOS Biology: published December 1, 2016 | https://doi.org/10.1371/journal.pbio.2000705

Accelerating Translational Research through Open Science: The Neuro Experiment

E. Richard Gold

PLOS Biology: published December 7, 2016 | https://doi.org/10.1371/journal.pbio.2001259

Research Articles

Getting Road Expansion on the Right Track: A Framework for Smart Infrastructure Planning in the Mekong

Andrew Balmford, Huafang Chen, Ben Phalan, Mingcheng Wang, Christine O’Connell, Cath Tayleur, Jianchu Xu

PLOS Biology: published December 15, 2016 | https://doi.org/10.1371/journal.pbio.2000266

Climate-Related Local Extinctions Are Already Widespread among Plant and Animal Species

John J. Wiens

PLOS Biology: published December 8, 2016 | https://doi.org/10.1371/journal.pbio.2001104

Selection for Mitochondrial Quality Drives Evolution of the Germline

Arunas L. Radzvilavicius, Zena Hadjivasiliou, Andrew Pomiankowski, Nick Lane

PLOS Biology: published December 20, 2016 | https://doi.org/10.1371/journal.pbio.2000410

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Shedding Light on the Grey Zone of Speciation along a Continuum of Genomic Divergence

Camille Roux, Christelle Fraïsse, Jonathan Romiguier, Yoann Anciaux, Nicolas Galtier, Nicolas Bierne

PLOS Biology: published December 27, 2016 | https://doi.org/10.1371/journal.pbio.2000234

The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications

Benoît S. Assogba, Pascal Milesi, Luc S. Djogbénou, Arnaud Berthomieu, Patrick Makoundou, Lamine S. Baba-Moussa, Anna-Sophie Fiston-Lavier, Khalid Belkhir, Pierrick Labbé, Mylène Weill

PLOS Biology: published December 5, 2016 | https://doi.org/10.1371/journal.pbio.2000618

Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation

Robin A. Sorg, Leo Lin, G. Sander van Doorn, Moritz Sorg, Joshua Olson, Victor Nizet, Jan-Willem Veening

PLOS Biology: published December 27, 2016 | https://doi.org/10.1371/journal.pbio.2000631

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A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression

Andreas Klaus, Dietmar Plenz

PLOS Biology: published December 6, 2016 | https://doi.org/10.1371/journal.pbio.1002582

Suppression of Dopamine Neurons Mediates Reward

Nobuhiro Yamagata, Makoto Hiroi, Shu Kondo, Ayako Abe, Hiromu Tanimoto

PLOS Biology: published December 20, 2016 | https://doi.org/10.1371/journal.pbio.1002586

Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

Angélique Richard, Loïs Boullu, Ulysse Herbach, Arnaud Bonnafoux, Valérie Morin, Elodie Vallin, Anissa Guillemin, Nan Papili Gao, Rudiyanto Gunawan, Jérémie Cosette, Ophélie Arnaud, Jean-Jacques Kupiec, Thibault Espinasse, Sandrine Gonin-Giraud, Olivier Gandrillon

PLOS Biology: published December 27, 2016 | https://doi.org/10.1371/journal.pbio.1002585

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Cell Fate Decision as High-Dimensional Critical State Transition

Mitra Mojtahedi, Alexander Skupin, Joseph Zhou, Ivan G. Castaño, Rebecca Y. Y. Leong-Quong, Hannah Chang, Kalliopi Trachana, Alessandro Giuliani, Sui Huang

PLOS Biology: published December 27, 2016 | https://doi.org/10.1371/journal.pbio.2000640

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Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity

Christopher J. Folts, Nicole Scott-Hewitt, Christoph Pröschel, Margot Mayer-Pröschel, Mark Noble

PLOS Biology: published December 15, 2016 | https://doi.org/10.1371/journal.pbio.1002583

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling

Liina Jakobson, Lauri Vaahtera, Kadri Tõldsepp, Maris Nuhkat, Cun Wang, Yuh-Shuh Wang, Hanna Hõrak, Ervin Valk, Priit Pechter, Yana Sindarovska, Jing Tang, Chuanlei Xiao, Yang Xu, Ulvi Gerst Talas, Alfonso T. García-Sosa, Saijaliisa Kangasjärvi, Uko Maran, Maido Remm, M. Rob G. Roelfsema, Honghong Hu, Jaakko Kangasjärvi, Mart Loog, Julian I. Schroeder, Hannes Kollist, Mikael Brosché

PLOS Biology: published December 6, 2016 | https://doi.org/10.1371/journal.pbio.2000322

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer

Wanil Kim, Andrew T. Ludlow, Jaewon Min, Jerome D. Robin, Guido Stadler, Ilgen Mender, Tsung-Po Lai, Ning Zhang, Woodring E. Wright, Jerry W. Shay

PLOS Biology: published December 15, 2016 | https://doi.org/10.1371/journal.pbio.2000016

Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

Kushol Gupta, Vesa Turkki, Scott Sherrill-Mix, Young Hwang, Grant Eilers, Louis Taylor, Charlene McDanal, Ping Wang, David Temelkoff, Robert T. Nolte, Emile Velthuisen, Jerry Jeffrey, Gregory D. Van Duyne, Frederic D. Bushman

PLOS Biology: published December 9, 2016 | https://doi.org/10.1371/journal.pbio.1002584

Meta-Research Article

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor

Lucile Vogt, Thomas S. Reichlin, Christina Nathues, Hanno Würbel

PLOS Biology: published December 2, 2016 | https://doi.org/10.1371/journal.pbio.2000598