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Table of Contents

February 2013

Cover

Molecular basis of FK506 inhibition of calcineurin.
Issue Image

Calcineurin (gray, catalytic A-subunit; beige, structural B-subunit) is the target of the most widely used immunosuppressant drug, FK506 (ball-and-stick model). FK506 and the viral inhibitor A238L (purple) share a common calcineurin substrate binding site, the LxVP site, which is located at the intersection of the two calcineurin subunits. The structure of the calcineurin:A238L complex led to an in-depth understanding of substrate binding and dephosphorylation by calcineurin. See Grigoriu, et al. (e1001492) in this issue.

Image Credit: Simina Grigoriu

Synopses

Which Came First, the Head or the Brain?

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Primers

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PLOS Biology: published February 26, 2013 | https://doi.org/10.1371/journal.pbio.1001498

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Community Page

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Daniel Gurnon, Julian Voss-Andreae, Jacob Stanley

PLOS Biology: published February 26, 2013 | https://doi.org/10.1371/journal.pbio.1001491

Research Articles

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Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

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