November 2007

Filopodia and lamellipodia are actin-rich protrusions important for cell motility. This electron micrograph shows exaggerated filopodia with club-like shape induced by formin mDia2 in cultured cells. These filopodia are filled with bundled actin filaments which were born in and converged from the lamellipodial network (see Yang et al., page e317).

Image Credit: Image by Lubov Czech, Tatyana Svitkina, and Changsong Yang using Adobe Photoshop software

Editorial

Poverty, Human Development, and Basic Biology

Liza Gross

PLOS Biology: published October 23, 2007 | https://doi.org/10.1371/journal.pbio.0050295

Synopses

Diminished Activity of RNA Polymerase III Selectively Disrupts Tissues with the Most Actively Dividing Cells

Lynne Marshall, Sarah J Goodfellow, Robert J White

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050286

A Genetic Basis for Hypersensitivity to “Sweaty” Odors in Humans

Liza Gross

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050298

Amyloid Peptide Toxicity in an Animal Model of Alzheimer Disease

Liza Gross

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050313

Omnidirectional Electric Fish

Kira E O'Day

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050314

Learning by Numbers in the Primate Cortex

Rachel Jones

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050319

A Candidate Gene for a Biological Marker of Schizophrenia in Mice

Liza Gross

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050320

Essay

Biology and Health Inequality

Eric Brunner

PLOS Biology: published October 23, 2007 | https://doi.org/10.1371/journal.pbio.0050267

Feature

Looking for Chinks in the Armor of Bacterial Biofilms

Don Monroe

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050307

Primer

Distorted Sex Ratios: A Window into RNAi-Mediated Silencing

Patrick M Ferree, Daniel A Barbash

PLOS Biology: published November 6, 2007 | https://doi.org/10.1371/journal.pbio.0050303

Community Page

The Costs of Exclusion: Recognizing a Role for Local Communities in Biodiversity Conservation

Marc Ancrenaz, Lisa Dabek, Susan O'Neil

PLOS Biology: published October 23, 2007 | https://doi.org/10.1371/journal.pbio.0050289

Research Articles

Genetic Elucidation of Human Hyperosmia to Isovaleric Acid

Idan Menashe, Tatjana Abaffy, Yehudit Hasin, Sivan Goshen, Vered Yahalom, Charles W Luetje, Doron Lancet

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050284

Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype

Akiko Watanabe, Tomoko Toyota, Yuji Owada, Takeshi Hayashi, Yoshimi Iwayama, Miho Matsumata, Yuichi Ishitsuka, Akihiro Nakaya, Motoko Maekawa, Tetsuo Ohnishi, Ryoichi Arai, Katsuyasu Sakurai, Kazuo Yamada, Hisatake Kondo, Kenji Hashimoto, Noriko Osumi, Takeo Yoshikawa

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050297

Mutation of RNA Pol III Subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and Disrupts Zebrafish Digestive Development

Nelson S Yee, Weilong Gong, Ying Huang, Kristin Lorent, Amy C Dolan, Richard J Maraia, Michael Pack

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050312

Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050290

Distinct Mammalian Precursors Are Committed to Generate Neurons with Defined Dendritic Projection Patterns

Wolfgang Kelsch, Colleen P Mosley, Chia-Wei Lin, Carlos Lois

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050300

Light Activates Output from Evening Neurons and Inhibits Output from Morning Neurons in the Drosophila Circadian Clock

Marie Picot, Paola Cusumano, André Klarsfeld, Ryu Ueda, François Rouyer

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050315

Complex Regulation of cyp26a1 Creates a Robust Retinoic Acid Gradient in the Zebrafish Embryo

Richard J White, Qing Nie, Arthur D Lander, Thomas F Schilling

PLOS Biology: published November 20, 2007 | https://doi.org/10.1371/journal.pbio.0050304

Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans

David J Begun, Alisha K Holloway, Kristian Stevens, LaDeana W Hillier, Yu-Ping Poh, Matthew W Hahn, Phillip M Nista, Corbin D Jones, Andrew D Kern, Colin N Dewey, Lior Pachter, Eugene Myers, Charles H Langley

PLOS Biology: published November 6, 2007 | https://doi.org/10.1371/journal.pbio.0050310

A sex-ratio Meiotic Drive System in Drosophila simulans. I: An Autosomal Suppressor

Yun Tao, John P Masly, Luciana Araripe, Yeyan Ke, Daniel L Hartl

PLOS Biology: published November 6, 2007 | https://doi.org/10.1371/journal.pbio.0050292

A sex-ratio Meiotic Drive System in Drosophila simulans. II: An X-linked Distorter

Yun Tao, Luciana Araripe, Sarah B Kingan, Yeyan Ke, Hailian Xiao, Daniel L Hartl

PLOS Biology: published November 6, 2007 | https://doi.org/10.1371/journal.pbio.0050293

Synthesis-Dependent Strand Annealing in Meiosis

Melissa S McMahill, Caroline W Sham, Douglas K Bishop

PLOS Biology: published November 6, 2007 | https://doi.org/10.1371/journal.pbio.0050299

Coordinate Gene Regulation during Hematopoiesis Is Related to Genomic Organization

Steven T Kosak, David Scalzo, Sam V Alworth, Fusheng Li, Stephanie Palmer, Tariq Enver, James S. J Lee, Mark Groudine

PLOS Biology: published November 20, 2007 | https://doi.org/10.1371/journal.pbio.0050309

Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control

HoJung Cho, Henrik Jönsson, Kyle Campbell, Pontus Melke, Joshua W Williams, Bruno Jedynak, Ann M Stevens, Alex Groisman, Andre Levchenko

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050302

Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells

Changsong Yang, Lubov Czech, Silke Gerboth, Shin-ichiro Kojima, Giorgio Scita, Tatyana Svitkina

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050317

Resolving the Fast Kinetics of Cooperative Binding: Ca²⁺ Buffering by Calretinin

Guido C Faas, Beat Schwaller, Julio L Vergara, Istvan Mody

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050311

Draft Crystal Structure of the Vault Shell at 9-Å Resolution

Daniel H Anderson, Valerie A Kickhoefer, Stuart A Sievers, Leonard H Rome, David Eisenberg

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050318

Omnidirectional Sensory and Motor Volumes in Electric Fish

James B Snyder, Mark E Nelson, Joel W Burdick, Malcolm A MacIver

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050301

Semantic Associations between Signs and Numerical Categories in the Prefrontal Cortex

Ilka Diester, Andreas Nieder

PLOS Biology: published October 30, 2007 | https://doi.org/10.1371/journal.pbio.0050294

Neuronal Activity in Rat Barrel Cortex Underlying Texture Discrimination

Moritz von Heimendahl, Pavel M Itskov, Ehsan Arabzadeh, Mathew E Diamond

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050305

Sleep-Related Hippocampo-Cortical Interplay during Emotional Memory Recollection

Virginie Sterpenich, Geneviève Albouy, Mélanie Boly, Gilles Vandewalle, Annabelle Darsaud, Evelyne Balteau, Thien Thanh Dang-Vu, Martin Desseilles, Arnaud D'Argembeau, Steffen Gais, Géraldine Rauchs, Manuel Schabus, Christian Degueldre, André Luxen, Fabienne Collette, Pierre Maquet

PLOS Biology: published October 23, 2007 | https://doi.org/10.1371/journal.pbio.0050282

An Information Theoretic Characterisation of Auditory Encoding

Tobias Overath, Rhodri Cusack, Sukhbinder Kumar, Katharina von Kriegstein, Jason D Warren, Manon Grube, Robert P Carlyon, Timothy D Griffiths

PLOS Biology: published October 23, 2007 | https://doi.org/10.1371/journal.pbio.0050288

Disruption of State Estimation in the Human Lateral Cerebellum

R. Chris Miall, Lars O. D Christensen, Owen Cain, James Stanley

PLOS Biology: published November 27, 2007 | https://doi.org/10.1371/journal.pbio.0050316

Correction

Correction: A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila

Eli Arama, Maya Bader, Gabrielle E Rieckhof, Hermann Stellar

PLOS Biology: published November 13, 2007 | https://doi.org/10.1371/journal.pbio.0050291

Cover

Filopodia filled with bundled actin filaments.

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