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Table of Contents

January 2007

Cover

A mouse with Cockayne syndrome.
Issue Image

Artist impression of the Csb/Xpa mouse model for the progeroid DNA repair disorder Cockayne syndrome. This animal model shows dwarf growth, neurological abnormalities, aging-associated pathology, and premature death. A comparison of the transcriptome of normal and mutant mouse livers revealed a novel link between genome instability and the age-related decline of the somatotroph axis (see van der Pluijm et al., e2).

Image Credit: Image by Ingrid van der Pluijm

Synopses

Manipulating Cellular pH Suggests Novel Anticancer Therapy

Liza Gross

PLOS Biology: published December 19, 2006 | https://doi.org/10.1371/journal.pbio.0050010

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A Simple Feedback Resistor Switch Keeps Latent HIV from Awakening

Richard Robinson

PLOS Biology: published December 26, 2006 | https://doi.org/10.1371/journal.pbio.0050025

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The Neural Cascade of Attentional Control

Janelle Weaver

PLOS Biology: published January 2, 2007 | https://doi.org/10.1371/journal.pbio.0050027

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Essay

Evolution, Interactions, and Biological Networks

Joshua S Weitz, Philip N Benfey, Ned S Wingreen

PLOS Biology: published January 16, 2007 | https://doi.org/10.1371/journal.pbio.0050011

Feature

Stem Cell Promise, Interrupted: How Long Do US Researchers Have to Wait?

Liza Gross

PLOS Biology: published January 16, 2007 | https://doi.org/10.1371/journal.pbio.0050032

Research Articles

Alternative 3′ Pre-mRNA Processing in Saccharomyces cerevisiae Is Modulated by Nab4/Hrp1 In Vivo

Karen S. Kim Guisbert, Hao Li, Christine Guthrie

PLOS Biology: published December 26, 2006 | https://doi.org/10.1371/journal.pbio.0050006

Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

Ingrid van der Pluijm, George A Garinis, Renata M. C Brandt, Theo G. M. F Gorgels, Susan W Wijnhoven, Karin E. M Diderich, Jan de Wit, James R Mitchell, Conny van Oostrom, Rudolf Beems, Laura J Niedernhofer, Susana Velasco, Errol C Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst

PLOS Biology: published December 12, 2006 | https://doi.org/10.1371/journal.pbio.0050002

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  1. Correction: Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

DNA Damage–Induced Bcl-xL Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH

Rui Zhao, David Oxley, Trevor S Smith, George A Follows, Anthony R Green, Denis R Alexander

PLOS Biology: published December 19, 2006 | https://doi.org/10.1371/journal.pbio.0050001

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Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles

Jeremiah J Faith, Boris Hayete, Joshua T Thaden, Ilaria Mogno, Jamey Wierzbowski, Guillaume Cottarel, Simon Kasif, James J Collins, Timothy S Gardner

PLOS Biology: published January 9, 2007 | https://doi.org/10.1371/journal.pbio.0050008

An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer

Leor S Weinberger, Thomas Shenk

PLOS Biology: published December 26, 2006 | https://doi.org/10.1371/journal.pbio.0050009

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The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling

Roberto Gherzi, Michele Trabucchi, Marco Ponassi, Tina Ruggiero, Giorgio Corte, Christoph Moroni, Ching-Yi Chen, Khalid S Khabar, Jens S Andersen, Paola Briata

PLOS Biology: published December 19, 2006 | https://doi.org/10.1371/journal.pbio.0050005

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  1. Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling

Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes

Xue-Ming Xu, Bradley A Carlson, Heiko Mix, Yan Zhang, Kazima Saira, Richard S Glass, Marla J Berry, Vadim N Gladyshev, Dolph L Hatfield

PLOS Biology: published December 26, 2006 | https://doi.org/10.1371/journal.pbio.0050004

Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors

Gaby Sennhauser, Patrick Amstutz, Christophe Briand, Otso Storchenegger, Markus G Grütter

PLOS Biology: published December 26, 2006 | https://doi.org/10.1371/journal.pbio.0050007

Timing and Sequence of Brain Activity in Top-Down Control of Visual-Spatial Attention

Tineke Grent-‘t-Jong, Marty G Woldorff

PLOS Biology: published January 2, 2007 | https://doi.org/10.1371/journal.pbio.0050012

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Correspondence

Author Sequence and Credit for Contributions in Multiauthored Publications

Teja Tscharntke, Michael E Hochberg, Tatyana A Rand, Vincent H Resh, Jochen Krauss

PLOS Biology: published January 16, 2007 | https://doi.org/10.1371/journal.pbio.0050018

Corrections

Correction: Interdigitated Paralemniscal and Lemniscal Pathways in the Mouse Barrel Cortex

Ingrid Bureau, Francisca von Saint Paul, Karel Svoboda

PLOS Biology: published January 16, 2007 | https://doi.org/10.1371/journal.pbio.0050028

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Correction: Asymmetrical Reinforcement and Wolbachia Infection in Drosophila

John Jaenike, Kelly Dyer, Chad Cornish, Miranda Minhas

PLOS Biology: published January 16, 2007 | https://doi.org/10.1371/journal.pbio.0050003

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