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Table of Contents

February 2006

Cover

Maria, a female orang-utan (Pongo pygmaeus) from Sabah in Malaysia.
Issue Image

The photograph depicts Maria, a female orang-utan living in the highly fragmented forest of the Kinabatangan Wildlife Sanctuary in eastern Sabah. Her future is in the hands of humankind, who clearly pushed the species to the brink of extinction during the last century, according to research reported in this issue of PLoS Biology. See Goosens et al.

Image Credit: Photo by Jamil Sinyor/KOCP

Editorial

Science in the News

Hemai Parthasarathy

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040055

Feature

Pandemic Influenza: The Inside Story

Henry Nicholls

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040050

Unsolved Mystery

Autophagy: A Forty-Year Search for a Missing Membrane Source

Gabor Juhasz, Thomas P Neufeld

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040036

Primer

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

Patrick E MacDonald, Patrik Rorsman

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040049

Related Articles

  1. Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion
  2. Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus
  3. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Research Articles

Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing

Rebeca Martinez-Contreras, Jean-François Fisette, Faiz-ul Hassan Nasim, Richard Madden, Mélanie Cordeau, Benoit Chabot

PLOS Biology: published January 10, 2006 | https://doi.org/10.1371/journal.pbio.0040021

Related Articles

  1. Looping Out Introns to Help Splicing

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

Orion D Weiner, Maike C Rentel, Alex Ott, Glenn E Brown, Mark Jedrychowski, Michael B Yaffe, Steven P Gygi, Lewis C Cantley, Henry R Bourne, Marc W Kirschner

PLOS Biology: published January 24, 2006 | https://doi.org/10.1371/journal.pbio.0040038

Related Articles

  1. Protein Complexes Help Point Migrating Cells in the Right Direction

Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus

Nora G Smart, Åsa A Apelqvist, Xueying Gu, Erin B Harmon, James N Topper, Raymond J MacDonald, Seung K Kim

PLOS Biology: published January 31, 2006 | https://doi.org/10.1371/journal.pbio.0040039

Related Articles

  1. A New Tile in the Biochemical Puzzle of Insulin Biology
  2. Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente

PLOS Biology: published December 27, 2005 | https://doi.org/10.1371/journal.pbio.0040031

Related Articles

  1. Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells
  2. The Sirt1 Gene Promotes Insulin Secretion in Accord with Diet
  3. Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells
  4. Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion

Jonathan V Rocheleau, Maria S Remedi, Butch Granada, W. Steven Head, Joseph C Koster, Colin G Nichols, David W Piston

PLOS Biology: published January 17, 2006 | https://doi.org/10.1371/journal.pbio.0040026

Related Articles

  1. Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells
  2. Potassium Channels Rule over Insulin Release with an Ion Fist

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

Min Hu, Lichuan Gu, Muyang Li, Philip D Jeffrey, Wei Gu, Yigong Shi

PLOS Biology: published January 17, 2006 | https://doi.org/10.1371/journal.pbio.0040027

Related Articles

  1. Structural Insights into the Regulation of a Key Tumor Suppressor

Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo

Richard Benton, Silke Sachse, Stephen W Michnick, Leslie B Vosshall

PLOS Biology: published January 17, 2006 | https://doi.org/10.1371/journal.pbio.0040020

Related Articles

  1. A Novel Design Principle for the Insect Odorant Receptor

Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion

Chris B Schaffer, Beth Friedman, Nozomi Nishimura, Lee F Schroeder, Philbert S Tsai, Ford F Ebner, Patrick D Lyden, David Kleinfeld

PLOS Biology: published January 3, 2006 | https://doi.org/10.1371/journal.pbio.0040022

Related Articles

  1. Redundancy in Cortical Surface Vessels Supports Persistent Blood Flow

Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex

Wei-Chung Allen Lee, Hayden Huang, Guoping Feng, Joshua R Sanes, Emery N Brown, Peter T So, Elly Nedivi

PLOS Biology: published December 27, 2005 | https://doi.org/10.1371/journal.pbio.0040029

Related Articles

  1. A New Window into Structural Plasticity in the Adult Visual Cortex
  2. Correction: Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex

Attenuation of Self-Generated Tactile Sensations Is Predictive, not Postdictive

Paul M Bays, J. Randall Flanagan, Daniel M Wolpert

PLOS Biology: published January 17, 2006 | https://doi.org/10.1371/journal.pbio.0040028

Related Articles

  1. Self-Generated Touch: A Neural Perspective

Genetic Signature of Anthropogenic Population Collapse in Orang-utans

Benoît Goossens, Lounès Chikhi, Marc Ancrenaz, Isabelle Lackman-Ancrenaz, Patrick Andau, Michael W Bruford

PLOS Biology: published January 24, 2006 | https://doi.org/10.1371/journal.pbio.0040025

Related Articles

  1. Genetic Evidence that Humans Have Pushed Orang-utans to the Brink of Extinction

Book Review%2FScience in the Media

The Bittersweet Sounds of the Modern Food Chain

Gavin Yamey

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040047