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October 2005

A scanning electron micrograph of Caulobacter crescentus cells at 10,000x magnification. Each cell division for C. crescentus is asymmetric, generating two distinct daughter cells: a motile swarmer cell and a sessile stalked cell. A systematic dissection of the signal transduction genes controlling cell cycle progression, growth, and morphogenesis is presented in Skerker et al.

Image Credit: Scanning electron micrograph by Jeffrey Skerker; false color by Liana Holmberg

Editorial

Published and Not Perished

Hemai Parthasarathy

Obituary

A Path to Discovery: The Career of Maclyn McCarty

Joshua Lederberg, Emil C Gotschlich

Primer

How the Ecdysozoan Changed Its Coat

John Ewer

Research Articles

Functional Genomic Analysis of C. elegans Molting

Alison R Frand, Sascha Russel, Gary Ruvkun

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Recombination Hotspots and Population Structure in Plasmodium falciparum

Jianbing Mu, Philip Awadalla, Junhui Duan, Kate M McGee, Deirdre A Joy, Gilean A. T McVean, Xin-zhuan Su

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Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

Haitao Yang, Weiqing Xie, Xiaoyu Xue, Kailin Yang, Jing Ma, Wenxue Liang, Qi Zhao, Zhe Zhou, Duanqing Pei, John Ziebuhr, Rolf Hilgenfeld, Kwok Yung Yuen, Luet Wong, Guangxia Gao, Saijuan Chen, Zhu Chen, Dawei Ma, Mark Bartlam, Zihe Rao

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Single-Nucleosome Mapping of Histone Modifications in S. cerevisiae

Chih Long Liu, Tommy Kaplan, Minkyu Kim, Stephen Buratowski, Stuart L Schreiber, Nir Friedman, Oliver J Rando

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Two-Component Signal Transduction Pathways Regulating Growth and Cell Cycle Progression in a Bacterium: A System-Level Analysis

Jeffrey M Skerker, Melanie S Prasol, Barrett S Perchuk, Emanuele G Biondi, Michael T Laub

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Drosophila Heartless Acts with Heartbroken/Dof in Muscle Founder Differentiation

Devkanya Dutta, Sanjeev Shaw, Tariq Maqbool, Hetal Pandya, K VijayRaghavan

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Dynamics of SNARE Assembly and Disassembly during Sperm Acrosomal Exocytosis

Gerardo A. De Blas, Carlos M Roggero, Claudia N Tomes, Luis S Mayorga

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The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals

Steven A Brown, Fabienne Fleury-Olela, Emi Nagoshi, Conrad Hauser, Cristiana Juge, Christophe A Meier, Rachel Chicheportiche, Jean-Michel Dayer, Urs Albrecht, Ueli Schibler

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Responses of Grassland Production to Single and Multiple Global Environmental Changes

Jeffrey S Dukes, Nona R Chiariello, Elsa E Cleland, Lisa A Moore, M. Rebecca Shaw, Susan Thayer, Todd Tobeck, Harold A Mooney, Christopher B Field

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Corrections

Correction: Traces of Archaic Mitochondrial Lineages Persist in Austronesian-Speaking Formosan Populations

Jean A Trejaut, Toomas Kivisild, Jun Hun Loo, Chien Liang Lee, Chun Lin He, Chia Jung Hsu, Zheng Yuan Lee, Marie Lin

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Correction: Directed Migration of Positively Selected Thymocytes Visualized in Real Time

Colleen M Witt, Subhadip Raychaudhuri, Brian Schaefer, Arup K Chakraborty, Ellen A Robey

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Book Review%2FScience in the Media

Bringing Evo Devo to Life

Paul M Brakefield