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Unveiling cancer crosstalk across spatial and temporal scales
This collection of comment, review and opinion articles focuses on how recent technological advancements in omics approaches (genomics, proteomics, metabolomics etc.) have enhanced our understanding of the mechanisms governing tumor progression across spatial and temporal scales, from tumorigenesis to metastatic dissemination. The articles cover diverse topics such as how single-cell and spatial omics approaches have shed light on the evolution of cancer clones and revealed the complexities of the crosstalk between cancer cells and the tumor microenvironment, how cellular metabolism is rewired to meet the demands of the tumor, and the mechanisms of metastatic spread to distant organs. The image shows immunofluorescence staining of human bone metastases sections showing cancer cells marked by CK8/CK19 (red), macrophages labeled with CD68 (green), and nuclei counterstained with DAPI (blue).
Image Credit: Yujiao Han and Yibin Kang, Princeton University
Citation: (2025) PLoS Biology Issue Image | Vol. 23(7) August 2025. PLoS Biol 23(7): ev23.i07. https://doi.org/10.1371/image.pbio.v23.i07
Published: August 6, 2025
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This collection of comment, review and opinion articles focuses on how recent technological advancements in omics approaches (genomics, proteomics, metabolomics etc.) have enhanced our understanding of the mechanisms governing tumor progression across spatial and temporal scales, from tumorigenesis to metastatic dissemination. The articles cover diverse topics such as how single-cell and spatial omics approaches have shed light on the evolution of cancer clones and revealed the complexities of the crosstalk between cancer cells and the tumor microenvironment, how cellular metabolism is rewired to meet the demands of the tumor, and the mechanisms of metastatic spread to distant organs. The image shows immunofluorescence staining of human bone metastases sections showing cancer cells marked by CK8/CK19 (red), macrophages labeled with CD68 (green), and nuclei counterstained with DAPI (blue).
Image Credit: Yujiao Han and Yibin Kang, Princeton University