Figures
ELF5 Drives Lethality in Breast Cancer
A study by David Gallego-Ortega, Christopher Ormandy and colleagues shows that up-regulation of the transcription factor ELF5 in tumors helps to create a micro-environment that recruits the innate immune system and increases vascular permeability, leading to increased metastasis in luminal breast cancer. Together with its role in anti-estrogen resistance, this suggests that ELF5 is a major driver of a lethal phenotype. The image shows metastasis nodules in the dissected lungs of a mouse model of mammary cancer that is overexpressing ELF5. The green fluorescence (EGFP) identifies the ELF5-expressing mammary cancer cells.
Image Credit: David Gallego-Ortega and Anita Ledger
Citation: (2015) PLoS Biology Issue Image | Vol. 13(12) December 2015. PLoS Biol 13(12): ev13.i12. https://doi.org/10.1371/image.pbio.v13.i12
Published: December 31, 2015
Copyright: © 2015 Gallego-Ortega and Ledger. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A study by David Gallego-Ortega, Christopher Ormandy and colleagues shows that up-regulation of the transcription factor ELF5 in tumors helps to create a micro-environment that recruits the innate immune system and increases vascular permeability, leading to increased metastasis in luminal breast cancer. Together with its role in anti-estrogen resistance, this suggests that ELF5 is a major driver of a lethal phenotype. The image shows metastasis nodules in the dissected lungs of a mouse model of mammary cancer that is overexpressing ELF5. The green fluorescence (EGFP) identifies the ELF5-expressing mammary cancer cells.
Image Credit: David Gallego-Ortega and Anita Ledger