Figures
The Intricate Workings of a Hippo Pathway Kinase
This illustration by poster artist Jay Ryan captures central points of structural and mechanistic analysis of an ancient signaling component of eukaryotic Hippo pathways. The enzyme complex is a dynamic allosterically-activated switch that recognizes specific short motifs in rapidly evolving intrinsically disordered protein regions. Motif recognition contributes robustness to regulatory links, and appears to allow disordered regions to act as reservoirs of variability where molecular docking interactions emerge and are adaptively retained. See Gógl et al.
Image Credit: Jay Ryan, The Bird Machine
Citation: (2015) PLoS Biology Issue Image | Vol. 13(5) May 2015. PLoS Biol 13(5): ev13.i05. https://doi.org/10.1371/image.pbio.v13.i05
Published: May 29, 2015
Copyright: © 2015 Ryan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This illustration by poster artist Jay Ryan captures central points of structural and mechanistic analysis of an ancient signaling component of eukaryotic Hippo pathways. The enzyme complex is a dynamic allosterically-activated switch that recognizes specific short motifs in rapidly evolving intrinsically disordered protein regions. Motif recognition contributes robustness to regulatory links, and appears to allow disordered regions to act as reservoirs of variability where molecular docking interactions emerge and are adaptively retained. See Gógl et al.
Image Credit: Jay Ryan, The Bird Machine