Figures
Molecular basis of FK506 inhibition of calcineurin.
Calcineurin (gray, catalytic A-subunit; beige, structural B-subunit) is the target of the most widely used immunosuppressant drug, FK506 (ball-and-stick model). FK506 and the viral inhibitor A238L (purple) share a common calcineurin substrate binding site, the LxVP site, which is located at the intersection of the two calcineurin subunits. The structure of the calcineurin:A238L complex led to an in-depth understanding of substrate binding and dephosphorylation by calcineurin. See Grigoriu, et al. (e1001492) in this issue.
Image Credit: Simina Grigoriu
Citation: (2013) PLoS Biology Issue Image | Vol. 11(2) February 2013. PLoS Biol 11(2): ev11.i02. https://doi.org/10.1371/image.pbio.v11.i02
Published: February 26, 2013
Copyright: © 2013 Grigoriu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Calcineurin (gray, catalytic A-subunit; beige, structural B-subunit) is the target of the most widely used immunosuppressant drug, FK506 (ball-and-stick model). FK506 and the viral inhibitor A238L (purple) share a common calcineurin substrate binding site, the LxVP site, which is located at the intersection of the two calcineurin subunits. The structure of the calcineurin:A238L complex led to an in-depth understanding of substrate binding and dephosphorylation by calcineurin. See Grigoriu, et al. (e1001492) in this issue.
Image Credit: Simina Grigoriu