Figures
Brain vasculature formation.
The formation of blood vessel networks in the midbrain is captured during development with in vivo long-term serial confocal imaging of intact transgenic zebrafish Tg(kdrl:eGFP), in which vascular endothelial cells express green fluorescent protein. The fate of each vessel segment and endothelial cell is traced in the 3-dimensional vasculature. Besides angiogenic sprouting (filopodium-like process), developing brain vasculature also undergoes extensive blood flow-driven vessel pruning (collapse-like segment), which simplifies the vessel network. This picture represents a projected image of the midbrain vasculature in a larval zebrafish. See Chen et al. (e1001374) in this issue.
Image Credit: Jiulin Du
Citation: (2012) PLoS Biology Issue Image | Vol. 10(8) August 2012. PLoS Biol 10(8): ev10.i08. https://doi.org/10.1371/image.pbio.v10.i08
Published: August 28, 2012
Copyright: © Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The formation of blood vessel networks in the midbrain is captured during development with in vivo long-term serial confocal imaging of intact transgenic zebrafish Tg(kdrl:eGFP), in which vascular endothelial cells express green fluorescent protein. The fate of each vessel segment and endothelial cell is traced in the 3-dimensional vasculature. Besides angiogenic sprouting (filopodium-like process), developing brain vasculature also undergoes extensive blood flow-driven vessel pruning (collapse-like segment), which simplifies the vessel network. This picture represents a projected image of the midbrain vasculature in a larval zebrafish. See Chen et al. (e1001374) in this issue.
Image Credit: Jiulin Du