Figures
Mcm1 (orange) combines with other transcription factors (blue) to regulate genes.
It is widely suspected that gene regulatory networks are highly malleable. To study this plasticity, the evolution of combinatorial gene regulation by Mcm1 and its cofactors was characterized in the yeast lineage (see Tuch et al, e38). In yeast species, Mcm1 (depicted in orange) combines with one of several other transcription factors (depicted in blue) to regulate genes acting in a diverse range of biological processes. Shown here are roughly a hundred of the approximately thousand nucleotide sequences bound by Mcm1 and its cofactors in three yeast species (S. cerevisiae, K. lactis, and C. albicans).
Image Credit: Image by Brian Tuch and Geraldine Kim
Citation: (2008) PLoS Biology Issue Image | Vol. 6(2) February 2008. PLoS Biol 6(2): ev06.i02. https://doi.org/10.1371/image.pbio.v06.i02
Published: February 26, 2008
Copyright: © 2008 Tuch, Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It is widely suspected that gene regulatory networks are highly malleable. To study this plasticity, the evolution of combinatorial gene regulation by Mcm1 and its cofactors was characterized in the yeast lineage (see Tuch et al, e38). In yeast species, Mcm1 (depicted in orange) combines with one of several other transcription factors (depicted in blue) to regulate genes acting in a diverse range of biological processes. Shown here are roughly a hundred of the approximately thousand nucleotide sequences bound by Mcm1 and its cofactors in three yeast species (S. cerevisiae, K. lactis, and C. albicans).
Image Credit: Image by Brian Tuch and Geraldine Kim