Fig 1.
The DNA sequence preference of SWR chromatin remodeler at promoters.
The SWR complex prefers to remove H2A-H2B dimers (orange) at the side of nucleosomes where there is a poly (dA:dT) tract (AAA…). SWR complex replaces the H2A-H2B dimer with an H2A.Z-H2B dimer (red). The incorporation of H2A.Z-H2B dimer at the side of the nucleosome closest to the start site of transcription causes that side of the nucleosome to be more prone for DNA to unwrap from the histone octamer and for the histone octamer to form a more open conformation. These changes in the nucleosome structure facilitates in transcription initiation.