Fig 1.
Timing of the studied events: (A) Mean log viral load measurements of TB-uninfected and LTBI patients and (B) fraction of OIs of TB-uninfected LTBI patients (see S3 Data for the underlying numerical values).
ART, antiretroviral therapy; LTBI, latent tuberculosis infection; OI, opportunistic infection; TB, tuberculosis.
Fig 2.
Description of the study population and the sensitivity analyses; B1 to B7 refer to the respective sections in S2 Text.
ART, antiretroviral therapy; LTBI, latent tuberculosis infection; SHCS, Swiss HIV Cohort Study; TB, tuberculosis.
Table 1.
Basic characteristics of the study populations: MTB uninfected patients, patients with LTBI, and patients with active TB.
Fig 3.
(A) Distribution of HIV SPVL values (log RNA) for patients with LTBI, active TB, and MTB uninfected patients. The lines indicated the density function of the log RNA values in the 3 studied groups. (B) Association of various factors with the log set point virus load; the lines indicate the 95% CIs obtained in the regression model; the dots indicate the regression coefficients. (see S3 Data for the underlying numerical values) CI, confidence interval; HET, heterosexual; IDU, intravenous drug users; LTBI, latent tuberculosis infection; MSM, men who have sex with men; MTB, Mycobacterium tuberculosis; SPVL, set point viral load; TB, tuberculosis.
Fig 4.
Association of the 10 most frequent OIs with TB infection: Patients with active TB and LTBI compared to MTB uninfected patients, respectively (active TB versus no TB, latent versus no TB).
The lines indicate the 95% CIs obtained through the logistic regression model; the dots indicate the ORs. (see S3 Data for the underlying numerical values) CI, confidence interval; LTBI, latent tuberculosis infection; MTB, Mycobacterium tuberculosis; OI, opportunistic infection; OR, odds ratio; TB, tuberculosis.
Fig 5.
Time-to-event analysis of the occurrence of candida stomatitis (A), oral hairy leukoplakia (B), and herpes zoster (C): Patients with active TB or LTBI compared to MTB uninfected patients, respectively.
The lines indicate the 95% CIs obtained through the cox proportional hazards model; the dots indicate the HRs. (see S3 Data for the underlying numerical values) CI, confidence interval; HR, hazards ratio; LTBI, latent tuberculosis infection; MTB, Mycobacterium tuberculosis; MV, multivariable; TB, tuberculosis; UV, univariable.