Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan
Fig 6
Cerebral blood perfusion and susceptibility to neurodegeneration.
(a) Comparison of perfusion with eight pathology-confirmed disease atrophy maps (voxel-based morphometry; VBM data from Harper et al. [159]), both parcellated using the Schaefer-400 functional atlas [126]. Colors indicate directions of association (red: positive, blue: negative) and asterisks indicate significant associations. (b) Late-onset Alzheimer’s disease (r = −0.43; FDR-corrected, ), (c) TDP-43C (r = −0.61; FDR-corrected,
), (d) and dementia with Lewy bodies (r = −0.37; FDR-corrected,
) show significant negative correlations with the perfusion map, indicating that these disease-specific atrophy patterns co-localize with areas of lower cerebral perfusion.