Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan
Fig 3
Blood perfusion co-localizes with molecular and cellular features.
(a) The top ten GO biological processes linked with gene sets correlated with perfusion [104]. Terms are sorted based on their associated category-scores. For a complete list of genes associated with a biological pathway, category-scores and statistics, see S4 Table. (b) Cell type enrichment analysis of the cortical perfusion score map [23]. For list of genes associated with a cell type, category scores and statistics, see S5 Table. Red lines indicate statistically significant associations (after FDR-correction). (c) Comparison of perfusion with maps of neurotransmitter receptors (from PET imaging) and neuropeptide receptors (from transcriptomics) [18,106]. Colors indicate directions of association (red: positive, blue: negative) and asterisks indicate significant associations. See S9 Fig for results obtained using a multivariate model with dominance analysis. Methodological details about each neurotransmitter receptor PET map are provided in S6 Table.