Low-dose mixtures of dietary nutrients ameliorate behavioral deficits in multiple mouse models of autism
Fig 6
Cocktail supplementation increases the diversity of activation patterns in the sociality-linked neurons of Tbr1+/− mice.
(A) Representative neuronal activity patterns of RSI-positive neurons in WT and Tbr1+/− mice. (B) Functional networks of WT and Tbr1+/− mice in RSI. Links (lines) between the nodes represent significant similarity in activation patterns relative to shuffled data. (C) Degree centrality of neurons in WT and Tbr1+/− mice across the RSI-1 and RSI-2 sessions. (D) Functional networks of WT and Tbr1+/− mice in OE. Links (lines) between the nodes represent significant similarity in activation patterns relative to shuffled data. (E) Degree centrality of neurons in WT and Tbr1+/− mice across the OE-1 and OE-2 sessions. The results of WT mouse #3 and Tbr1+/− mouse #4 are presented as examples. Data in (C) and (E) are presented as means ± SEM. The data points of individual neurons are also shown. Two-way ANOVA with Bonferroni post hoc test was used for statistical analysis. ** P < 0.01; *** P < 0.001; **** P < 0.0001. See also S8 and S9 Figs. The data underlying the figure can be found in the S3 Data. All statistical analyses and results, including the actual P-values, are summarized in S4 Data.