A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns

doi:10.1371/journal.pbio.3003228

A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns

Fig 2

Ectopic transgene expression across model systems.

(A–D) On the left panels: example brain slices showing ectopic expression in Dbh^cre/Net^cre/Th^cre/PRS×8 model systems. Immuno-staining against GFP and TH is displayed in green and magenta, respectively. On the right panels: summary of ectopic expression across all mice in Dbh^cre/Net^cre/Th^cre/PRS×8 model systems. Brain regions are color-coded to reflect the number of mice which showed ectopic expression (at least 1 neuron) in the corresponding brain region. Brain slice images from [37].

doi: https://doi.org/10.1371/journal.pbio.3003228.g002