Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo
Fig 3
Coupling of the circadian clock to the cell cycle and the proteome.
(A) Distribution of predicted time labels for the samples in each AC. (B) Difference in time labels predicted by COFE between cancer and patient-matched healthy samples, where both are available. (C) Scores for cell cycle phases (S and G2/M) in the different ACs. The raw and LOESS-smoothed scores per sample are shown. (D) The number of rhythmic and total measured proteins in each AC. (E) The amplitude of rhythmic protein expression (color coded as in (A)) for proteins including modified forms that are rhythmic in at least 10 of the 11 ACs. (F) The raw data and LOESS-smoothed means for the rhythmic protein with the highest amplitude in each AC. (G) Distribution of the difference in peak times of expression of rhythmic proteins and their corresponding rhythmic gene. The data underlying Figure panels can be found in S1 Data.