Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo
Fig 2
Circadian population rhythms in human adenocarcinomas (ACs).
(A) Demographics of patients, whose biosamples provided data for training COFE. (B) Number of rhythmic genes and rhythmic core clock genes identified in each AC. (C) Cumulative distribution of the rhythmic gene amplitudes in different ACs. (D) Consensus amplitude and peak times of 15 commonly expressed core clock genes across the ACs (left). The dispersion of peak times of clock genes from the consensus arrangement across the ACs (middle). The relative strength of core clock network in different ACs (right). (E) Intersection of rhythmic gene sets across 11, 10 and 9 different ACs. (F) Reactome-based gene-set enrichment analysis of the common rhythmic genes. (G) Variability of peak times of genes within a pathway compared against the variability of peak times with respect to the core clock in different ACs. The data underlying Figure panels can be found in S1 Data.