Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo
Fig 1
Workflow of Cyclic Ordering with Feature Extraction (COFE).
Data without time labels are first optionally pre-filtered and then standardized. A novel cross-validation approach finds a value for the unknown sparsity parameter that guarantees good temporal ordering. Finally, COFE both assigns time labels to the samples and produces a list of rhythmic features in the data.