Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism
Fig 9
Summary of the seizure evolution in Cyfip2+/R87C mice.
Seizure phenotypes in Cyfip2+/R87C mice begin with infantile spasms during the neonatal stage (PWK 1), followed by a seizure-free latent period during the juvenile and young adult stages. Around PWK 14, Cyfip2+/R87C mice start to exhibit spontaneous recurrent seizures, which worsen with age and are associated with premature death. This seizure evolution is accompanied by various temporal cellular and molecular changes in the brain, including alterations in neurons, glial cells, and their lipid and metabolic profiles, which may interact to contribute to the seizure phenotype.