Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans
Fig 3
Evolution and conservation of essentiality.
(A) Histogram of essentiality score as in Fig 2F, split by conservation status in humans. Genes without human orthologs are shown at top and those with human orthologs are shown below. (B) Genes with orthologs in S. cerevisiae, C. albicans, S. pombe and C. neoformans where the orthologs are essential in all three ascomycetes but predicted dispensable in C. neoformans. (C) Genes with orthologs in S. cerevisiae, C. albicans, S. pombe and C. neoformans where the orthologs are dispensable in all three ascomycetes but predicted essential in C. neoformans. Trees depicted in B–C are not inferred here but are based on the accepted relationship between these fungal groups [97]. Data underlying A can be found in S1 Table. Data underlying B–C can be found in S4 Table.