Two distinct subpopulations of human stem-like memory T cells exhibit complementary roles in self-renewal and clonal longevity
Fig 8
Fit of the three viable models – Model C (fork), Model D (linear, CD95int first) and Model E (linear, CD95hi first) – to all data (labelling, telomere, YFV) simultaneously.
(A) Fit of models to the labelling data (each individual in a different row, each cell population in a different column); black dots represent data, colored lines represent fitted model predictions (solid: Model C, dashed: Model D, dotted: Model E). (B) Fit of models to the telomere data. Observed differences in mean telomere length between TN and TSCM for 5 individuals shown on the left in black, predictions for each individual and each model shown by colored points on the right (DW19 in blue, DW20 in pink, DW25 in orange. squares: Model C, diamonds: Model E, triangles: model D). (C) Fit of the model to the YFV data. Observed data (YFV-specific TSCM as a % of CD8+ T cells) shown by black points, fitted model predictions for each individual shown by colored lines (DW19 in blue, DW20 in pink, DW25 in orange) and for each model shown by line type (solid: Model C, dashed: Model D, dotted: Model E). The data underlying this figure can be found in S1 Data.