Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth
Fig 6
Summary of permeability selection results for the archaeal and hybrid membranes.
(A and B) show the lipid compounds used for vesicle construction and permeability comparisons. (C and D) summarize permeability function. Pentose sugars are notated as pentagons, hexose sugars as hexagons, and amino acids as circles. Arrows indicate permeability function across the various membranes where wider blue (l) or red (d) arrows denote a significant differential enantiomer permeability selection. Benjamini–Hochberg corrected statistical significance are shown using the star convention (*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001), see Table 1. Key indicates which arrow side represents which enantiomer. Compounds colored orange indicate enantiomer selection that matches the core biochemistry of life. We have added glycine here based on results from our previous work. Glycine has no stereochemistry and has been shown to permeate both the archaeal and hybrid membrane [79].