Brief early-life motor training induces behavioral changes and alters neuromuscular development in mice
Fig 6
Training impact on spontaneous network activity in spinal motor networks of P3 mice.
A. Representative traces of spontaneous excitatory post-synaptic currents (sEPSCs) recorded in the presence of strychnine and gabazine in an untrained (black trace) and a trained (purple trace) MN held at −60 mV (VH −60 mV) (A1). Cumulative distributions of sEPSC frequency (A2) and amplitude (A3) recorded in untrained (black dots, n = 20) and trained (purple dots, n = 14) MNs. B. Representative traces of spontaneous inhibitory post-synaptic currents (sIPSCs) recorded in the presence of DNQX and AP5 in an untrained (black trace) and a trained (purple trace) MN held at −90 mV (VH −90 mV). Cumulative distributions of sIPSC frequency (B2) and amplitude (B3) recorded in untrained (black dots, n = 24) and trained (purple dots, n = 11) MNs. * Significantly different. ***p < 0.001, and ****p < 0.0001, Kolmogorov–Smirnov test. Underlying data can be found in the S1 Data Sheet.