Brief early-life motor training induces behavioral changes and alters neuromuscular development in mice
Fig 5
Training impact on the ADSP expression at VLF-MNs synapses.
A. Schematic diagram of the experimental protocol and sample traces of EPSCs elicited during paired-pulse stimulations of VLF axons (VLF stim, 50 ms interval, black dots) in lumbar MNs held at −60mV before and after VLF-HFS (50 Hz, 2 s, middle trace). B. Pooled data average time courses of normalized VLF-EPSC amplitudes in VLF-MNs synapses expressing LTD (green dots) or LTD (blue dots) in untrained mice. C. Pooled data average time courses of normalized VLF-EPSC amplitudes in VLF-MNs synapses expressing LTD (green dots), STD (blue dots) or no plasticity (red dots) after VLF-HFS in trained mice. D. Percentage of different ADSPs expressed by untrained (bars with black border, n = 25) and trained (bars with purple border, n = 37) MNs. * Significantly different. *p < 0.05, Chi square test. Underlying data can be found in the S1 Data Sheet.