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Feedback from an avatar facilitates risk-taking by modulating the amygdala response to feedback uncertainty
Fig 7
Feedback uncertainty-correlated activity in the vSTR and vACC.
(a, d) Differential activity correlated with feedback uncertainty (avatar–human) was weighted by the differential behavioral coefficient (valuation) for feedback uncertainty (i.e. 
). Significant activity was identified in the vSTR (a) (peak MNI coordinates: [6,16, −4], FWE-corrected p = 1.5 × 10-5) and the vACC (d) (peak MNI coordinates: [−6, 42, −12], FWE-corrected p = 0.030). (b, e) Activity correlated with differential feedback uncertainty at the center of independent anatomical ROI of the vSTR (b) and vACC (e) is plotted against the differential feedback uncertainty coefficient (i.e. 
). (c, f) Responses (beta values) of the vSTR (c) and vACC (f) to feedback uncertainty are displayed separately for the avatar and human conditions within RTA and RTH, following the same format as in Fig 5d. In the vSTR (c), feedback uncertainty-correlated activity was negative in the human condition of RTH (p = 0.024, t = −2.10) but not in the avatar condition of RTA (p = 0.15, t = −1.02). No significant difference was found between the avatar and human conditions in RTA (p = 0.075, t = −1.85). In the vACC (f), feedback uncertainty-correlated activity showed no significant difference between the avatar and human conditions in either RTA or RTH. The asterisk indicates statistical significance. Numerical data are provided in S2 Data (b, d).
doi: https://doi.org/10.1371/journal.pbio.3003122.g007