Identification of a novel lipoic acid biosynthesis pathway reveals the complex evolution of lipoate assembly in prokaryotes
Fig 6
Phylogenetic trees for LipS1/S2.
(a) To investigate the evolution of LipS1 and LipS2, their sequences were concatenated, as both units are usually found in synteny, are catalytically active together and should therefore be under the same evolutionary pressure [29]. Incomplete sequences and concatenated sequences from genomes lacking either LipS1 or LipS2 were removed from the analysis. The lower panels show schematic representation of phylogenetic trees generated using only archaeal sequences (red, b) or bacterial sequences (blue, c). Bacterial clades represented by single sequences were left out to increase readability. The data underlying this figure is provided in S3 Data.