Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression
Fig 5
Physiological properties of mice (n = 4 for each condition) were assessed on the seventh day of their active phase (ZT12 to 22 hours) using an HD-X10 DSI telemetry system. We measured (A) CBT, (B) HR, (C) systolic and diastolic BP, and (D) activity using an average 1-hour bin analysis after exposing the mice to IH. Although systolic and diastolic BP and activity did not show any significant differences in any time bins between normoxia and IH, CBT and HR did show significant differences (p ≤ 0.05, two-way ANOVA) across several time bins. In addition, we also observed an overall significant increase (p ≤ 0.05, two-way ANOVA) in CBT following IH exposure. Data for Fig 5A–5D can be found in S7 Data. BP, blood pressure; CBT, core body temperature; HR, heart rate; IH, intermittent hypoxia; ZT, Zeitgeber time.