Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Fig 5
Comparison of the structures of complexes formed by the spike protein ectodomain with the ACE2 ectodomain, VH ab8, and Fab ab1.
(A–C) Open-face views of the receptor binding domain (RBD) from the vantage point of ACE2 (A), VH ab8 (B), and Fab ab1 (C), with the residues involved in contact shaded in red, yellow, and blue, respectively. (D–F) Space-filling model view of ACE2 (D), VH ab8 (E), and Fab ab1 (F) in contact with the RBD (structure shown in ribbon format). (G) Superposition of the structures of the complex of the RBD with ACE2, VH ab8, and Fab ab1 to show their relative footprints on the RBD surface.