Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice
Fig 9
Effects of pharmacological lesioning of the nasal epithelium on the development of OB–LEC activity.
(A) Schematic drawing of experimental protocol. (B) Power spectra (mean ± SEM) of LFP recorded in OB (left) and LEC (right) of methimazole- (gray) and saline-treated (black) mice. (C) Box plots displaying power of RR (green) and theta bursts (purple) recorded in OB of methimazole- (gray) and saline-treated (black) mice. (D) Same for RR and theta bursts recorded in LEC. (E) Box plots displaying MUA frequency in OB and LEC of methimazole- (gray) and saline-treated (black) animals. (Wilcoxon rank-sum test, *p < 0.05; **p < 0.01). Data are available in S1 Data. I.P., intraperitoneal; LEC, lateral entorhinal cortex; LFP, local field potential; MUA, multiunit activity; OB, olfactory bulb; RR, respiration-related rhythm.