Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Fig 3
Subcellular model of the location of lipid peroxidation in ferroptosis.
The red question marks represent the unsolved mysteries discussed in the article. 4-HNE, 4-hydroxynonenal; MDA, malondialdehyde; PL-PUFA(PE)-OOH, polyunsaturated-fatty-acid-containing-phospholipid hydroperoxides; ROS, reactive oxygen species.