Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Fig 2
Fenton chemistry and lipid peroxidation in ferroptosis.
There are three steps involved in nonenzymatic lipid peroxidation. The first step is the generation of lipid radicals (initiation). The second step is the creation of new lipid radicals (propagation). The final step is termination, either by antioxidants or another radical. PUFA, polyunsaturated fatty acid.