POMC neurons in heat: A link between warm temperatures and appetite suppression
Fig 2
Model for the role of TRPV1-like receptors on POMC neurons in appetite suppression.
Elevated core body temperature above 37°C is transduced by POMC neurons via TRPV1-like receptors, heteromers of TRPV1 and TRPV3/4. Increased activity in POMC neurons causes increased melanocortin signaling in downstream second order neurons that promote satiety. 3V, third ventricle; αMSH, α-melanocyte stimulating hormone; POMC, pro-opiomelanocortin; TRPV1, transient receptor potential vanilloid 1.