The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3
Fig 5
Arc expression correlates with memory performance (D2 ratios).
Arc expression in (A) distal CA1—the area hypothesized to primarily process temporal information—strongly correlates with the temporal D2 scores, whereas no other hippocampal region does. In contrast, (B) proximal CA1 and (C and D) both parts of CA3—candidate areas for spatial information processing—correlate with the spatial discrimination index (spatial D2), whereas distal CA1 does not (S2 Fig for nonsignificant correlations; underlying data in Supporting Information S2 and S3 Data).