Gut microbiome transition across a lifestyle gradient in Himalaya
Fig 5
Distinctions in the gut microbiome across lifestyles.
(A) Phyla with most significant differences in abundances between the five populations. Abundances of Firmicutes, Verrucomicrobia, and Actinobacteria reflect gradients of traditional industrialized lifestyles. Proteobacteria distinguishes rural Himalayan populations from the Americans. (B) Heatmap displaying 52 genera with significantly different abundance across the five populations. Bars on the top represent the grouping of individuals in the heatmap columns by their populations or lifestyles. Genera labels in rows are colored by their phylum. Purple, Actinobacteria; dark blue, Bacteroidetes; light red, Elusimicrobia; orange, Firmicutes; light blue, Proteobacteria; magenta, Spirochaetes; light pink, Tenericutes; brown, Verrucomicrobia. Heatmap colors reflect relative abundances of each genus. Among the Himalayan populations, Ruminobacter, Campylobacter, unknown Veillonellaceae genus, Bulleidia, Weissella, Treponema, Barnesiella, Odoribacter, Alistipes, and Bifidobacterium differed significantly. The data underlying this figure can be found in S6 and S7 Tables.