A map of protein dynamics during cell-cycle progression and cell-cycle exit
Fig 5
Data synthesis to generate maps of protein dynamics during cell-cycle progression and cell-cycle exit.
(A) Moving average traces from Fig 3 Column 2 were normalized such that the minimum signal experienced across CDK2inc and CDK2low data for a given protein was set to 0, and the maximum signal experienced across CDK2inc and CDK2low data for this protein was set to 1. The approximate time spent in G1, S, or G2 phases is marked above the plots, based on EdU incorporation data from Fig 1H. Group 1 (top row): protein signals that are “off” in quiescent cells. Group 2 (bottom row): protein signals that change dynamically over time in quiescent cells. (B) Schematized representation of the data from (A).