High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance
Fig 8
Inhibition of nucleotide homeostasis amplifies the consequences of DNA damage, increasing the toxicity of DNA-damaging agents.
Trimethoprim treatment (orange graphics) blocks DNA repair, which is induced by azidothymidine (AZT) treatment (blue graphics). The combined effects result in increased growth inhibition relative to single-agent treatment.