High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance
Fig 3
Trimethoprim and azidothymidine (AZT) act synergistically in clinical strains that do not respond to trimethoprim and sulfamethizole.
(A) Trimethoprim + sulfamethizole. (B) Trimethoprim + AZT. Synergistic fractional inhibitory concentration index (FICI) values (≤0.5) are marked with yellow bars, and nonsynergistic (FICI > 0.5) FICI values are marked with blue bars. Trimethoprim/sulfamethizole-resistant isolates are labeled with red text and sensitive isolates are labeled with black text. Average FICI scores are shown in the graph. Individual FICI scores are shown in S6 Table.