Cell Fate Decision as High-Dimensional Critical State Transition
Fig 4
Critical Slowing down of state relaxation during fate commitment.
Apparent critical slowing down of relaxation and restoring of parental distribution of the sorted Sca1-low outlier fraction in the treated population. Clonal EML progenitor cells were stimulated (top) with GM-CSF/IL-3 or not (bottom), and cells with lowest 15% Sca1 expression were FACS-sorted one day after stimulation.