Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
Fig 7
Schematic of the proposed mechanism of lactate effects on T cells in the inflammatory site.
(A) The motility of CD4+ and CD8+ T cells is blocked once they get exposed to elevated levels of lactate in the inflammatory site. Lactic acid also causes loss of cytolytic activity by CD8+ T cells, and sodium lactate promotes the production of IL-17 by CD4+ T cells. (B) Pharmacologic targeting of lactate transporters re-establish T cell migration away from the inflammatory site and block the production of high amounts of IL-17.