A Modular Library of Small Molecule Signals Regulates Social Behaviors in Caenorhabditis elegans
Figure 4
Indole ascarosides mediate aggregation behavior in C. elegans.
(A) Aggregation behavior of solitary and social hermaphrodites at low worm densities (20 worms per plate) on different concentrations of icas#3. (B) Aggregation behavior of solitary and social hermaphrodites at high worm densities (∼120 worms per plate) on different concentrations of icas#3. (C) Aggregation of daf-22 hermaphrodites at low worm density on two different concentrations of icas#3. (D) Mean stopped duration of N2 hermaphrodites at different icas#3 concentrations (Figure 4A–D: *p<0.05, **p<0.01 one-factor ANOVA with Dunnett's post-test). (E) Aggregation (red arrow) of N2 hermaphrodites (20 worms per plate) on plates containing 10 pM of icas#3 compared to behavior on control plates. (F) Aggregation of N2 hermaphrodites (∼120 worms per plate) on plates containing 1 pM of icas#3 compared to behavior on control plates.