Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
Figure 9
The molecular mechanism of transcriptional activation by MLL fusion proteins.
MLL fusions recruit EAP core components and cause H3K79 methylation as well as Pol II CTD phosphorylation at serine 2. As a consequence, target genes are continuously expressed, inhibitory H3K27 and H3K9 methylation does not take place, and hematopoietic precursors are blocked for differentiation. The amino acid sequence of a single repeat unit in the CTD is given in the one letter code.