Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila
Figure 5
Antagonistic Transcriptional Regulation of brummer Lipase in Response to AKH/AKHR Lipolytic Signaling
(A) Moderate transcriptional up-regulation of bmm in control flies (AKHRrev) after 6 h food deprivation, but starvation-induced hyperstimulation of bmm transcription in obese AKHR mutants (AKHR1) and flies lacking the AKH-producing neuroendocrine cells (AKH-ZD). By contrast, bmm transcription in lean flies chronically expressing AKH in the fat body (B) is strongly reduced.