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Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

Figure 10

Dependence of the Affinity of a Series of meta- and para-Substituted Fluorophenolates for KSI ^D40N on p K _a

Data for pKSI ^D40N is shown in (A) and data for tKSI ^D40N is shown in (B), with slopes of 0.11 ± 0.03 and 0.10 ± 0.03, respectively.

doi: https://doi.org/10.1371/journal.pbio.0040099.g010