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Dorsoventral Patterning of the Mouse Coat by Tbx15

Figure 6

Effect of de^H on Agouti Expression

Comparable sections from a^t/a^t; de^H/de^H and a^t/a^t; +/+ littermates.

(A) At E14.5, de^H/de^H embryos have a smaller body cavity and loose skin within which Agouti expression appears to be shifted dorsally, as marked by arrows (scale bars = 500 μm).

(B) At P4.5, Agouti expression in both dorsal and ventral skin is similar in de^H/de^H compared to nonmutant, but in the midflank region, there is increased Agouti expression in de^H/de^H, especially in the upper dermis (scale bars = 200 μm). Sections shown are representative of two mutant and two nonmutant samples examined at each time.

doi: https://doi.org/10.1371/journal.pbio.0020003.g006